Accomplishments Timeline










  • First drug target, the APP gene, identified by Dr. William Mobley and researchers at Stanford University, linking cognitive impairment in DS to the cognitive decline experienced in Alzheimer’s disease


  • DSRTF awards grant to Dr. William Mobley (at the time with  Stanford University, but currently at the University of California San Diego)


  • New mouse model for Down syndrome research developed by researchers in London


  • Decoding of human genome announced making cognitive research for Down syndrome more productive

Research Results

As recently as 2004 there were no defined biological mechanisms known to have a direct correlation with cognitive impairment in Down syndrome, and as a result, no drug targets suitable for drug discovery and development. Since our founding in 2004 and over $9.6 million in research funding generated by DSRTF supporters, dramatic progress has been made. There are now five independent studies showing the promise for improving cognitive function for individuals with Down syndrome. Click here to learn more about our results.


Financial Highlights

DSRTF has become the leading non-governmental source of funding in the U.S. for research to improve cognition in individuals with Down syndrome. Since its founding in 2004, DSRTF has generated more than $9 million to fund and support major new results-driven cognition research.

For a copy of DSRTF's IRS 990 form for FY 2012, please e-mail us or visit


Research Institutions

Stanford University School of Medicine
More than $4.4 million total funding since 2004

Johns Hopkins University School of Medicine
More than $1.35 million total funding since 2007

University of Arizona
More than $440,000 total funding since 2008

University of California San Diego School of Medicine
More than $700,000 total funding since 2009

University of Texas, Austin

VA Palo Alto Health Care System

Down Syndrome Research and
Treatment Foundation

225 Cedar Hill Street, Suite 200  Marlborough, MA  01752
Phone: 508.630.2177

© 2012 Down Syndrome Research and Treatment Foundation. All Rights Reserved.