About DSRTF :: Accomplishments

Although in existence for only two years, DSRTF is the largest source of private funds for Down syndrome cognition research. We attribute this success to our focused mission, which is to understand and treat the deficiencies in learning, memory and speech experienced by those with DS.

DSRTF grants have moved the field forward by enabling scientists to complete experiments with mouse models of Down syndrome that have proven:

• the structure and formation of synapses in a Down syndrome brain are abnormal;
• synaptic function and strength are disrupted;
• cholinergic neurons degenerate, and this degeneration is due to the failure to send neurotrophic signals;
• removal of an extra copy of a critical gene on chromosome 21 improved cognitive functioning significantly;
• long-term protentiation, a cellular basis for learning and memory, is severely impaired, and this change is caused by an enhanced efficiency in inhibitory neurotransmission in the brain.

Research currently taking place with DSRTF grant money includes studies to determine:

• why changes in inhibitory neurotransmission reduce learning and memory in people with Down syndrome, and what compounds can be used to “turn down” this inhibition in the brain;
• the causes of reduced nerve growth factor (NGF) in Down syndrome and possible ways to devise treatments;
• why the overproduction of certain proteins lead to differences in the synaptic function of the brain, and how certain drugs could prevent the over-production of these proteins.

While the exciting progress that has been made in the field in a very short time is encouraging, it also underscores the neglect that the field suffered until just recently, and indicates the strong potential for identifying treatments in the near future.

DSRTF itself has made significant strides since it’s founding two years ago. DSRTF’s accomplishments include:

• raising more than $1.5 million of private funds for DS cognition research;
• influencing an additional $4 million from public and private sources for DS studies or DS cognition research resources;
• development of a grassroots fundraising network throughout the country which includes over 1000 donors to-date;
• the successful Adopt-a-Mouse program which raises awareness of the need for funds and for specific resources, like mouse models, to enable this promising research to take place;
• hosting a number of educational and fundraising activities across the country including events in Boston, Washington D.C, Charlotte, Dallas, Phoenix and San Francisco; sponsoring Congressional testimony about the importance and promise of DS cognition research and playing a lead role in an NIH workshop to determine funding priorities for DS research.

DSRTF is proud of our role in ensuring that this promising work will continue to progress. Join us in being part of the breakthrough.